UC2 (Undenatured Collagen Type 2) for Osteoarthritis: A Review of the Evidence

Osteoarthritis (OA) is a prevalent degenerative joint disorder characterized by the breakdown of cartilage, leading to pain, stiffness, and reduced joint function. Traditional management focuses on symptom relief, but emerging research suggests a promising role for UC2 (Undenatured Collagen Type 2) in addressing the underlying pathology. This article provides a thorough review of the evidence supporting the use of UC2 for osteoarthritis, exploring its mechanisms of action, safety profile, and clinical efficacy.

Osteoarthritis poses a significant health burden worldwide, affecting millions of individuals, predominantly in the aging population. While current therapies primarily target symptom management, the pursuit of interventions addressing the fundamental causes of OA has led to the investigation of UC2, an undenatured form of collagen type 2.

UC2 is a natural protein found in cartilage, providing structural support and maintaining joint integrity. Unlike denatured collagen, UC2 retains its native conformation, preserving its bioactive properties. Studies suggest that UC2 acts as an oral tolerogen, modulating the immune response and reducing the inflammatory cascade that contributes to cartilage degradation in OA.